Session Chair: Dr James Birchall, Cardiff University
Microneedle delivery of virus-like-particle vaccines for pandemic flu

Delivering biotherapeutics to the patient
Speaker:  Dr Kevin King, Pfizer

Short Papers from submitted Abstracts:

	Pharmaceutical Nanomaterials: The preparation of solid core drug delivery systems (SCDDS) John Mitchell Polymer Microparticle Production in CO2 - In Search of the Perfect Injection Mark Whitaker

 

Session Chair: Dr Marcel de Matas, University of Bradford

Pharmaceutical Cocrystals to Modify Physico-Chemical and Dissolution Profile of APIs
Speaker: Professor Ashwini Nangia, University of Hyderabad, India

Short Papers from submitted Abstracts:

	Effects of speciation on the freeze drying properties of lyophiles Dr Richard Storey The influence of API isolation and drying methods post crystallistion on API properties and performance during drug product processing Mr Arulsuthan Balasundaram Solid Dispersions - Molecular Distribution and crystal habit modification Mrs Wedad Ali

Poster Bites:

	The Characterisation of Slow Crystallisation of Lipidic Solid Dispersion Systems using Quasi-Isothermal MTDSC Sarah Otun Nano-characterisation of phase separation in pharmaceutical solid dispersion films Dr Sheng Qi

 

Session Chair: Professor Adrian Davis, Limeway Consulting

Bioavailability issues in dermal delivery, academic, industrial and regulatory perspectives

Speakers:	Professor Richard Guy, University of Bath
	Mr Sean Jones, MHRA

Trans(Dermal) bioavailability
An overview will describe the problems associated with determining topical and transdermal drug delivery. In vitro release tests and in vitro skin permeation studies will be discussed in the context of their applicability to predict in vivo performance. A brief outline will be provided on the problems associated with the use of in vivo assessments of bioavailability using tape stripping and microdialysis. Future prospects in the determination of topical bioavailability will be described.
Speaker: Professor Jonathan Hadgraft, University of London
 

Session Chair: Dr Arthur Andrews, Joint Pharmaceutical Analysis Group

Physiochemical characterisation of disperse systems (45 min)
Speaker: Professor Graham Buckton, University of London

Emerging trends; characterisation of mesoporous silica inclusion compounds (45 min)
Speaker: Professor Johan Martens, University of Leuven, Belgium

Short Papers from submitted Abstracts:

	LC Purity and Related Substances Screening for Mephedrone Mr Nagendra Singh Method Development for Analysis of Lactose Aerodynamic Particle Size Distributions in Dry Powder Inhaler Products Miss Victoria Heath

 

Session Chair: Dr Barry Moore, Xstalbio

Use of thermal and other analytical methods in optimising protein formulations
Speaker: Dr Paul Matejtschuk, Health Protection Agency

Process Development strategies for Novel Antibody formats
Speaker: Dr Ahmed Yasin, GlaxoSmithKline

Short Papers from submitted Asbtracts:

	Development of Methods for the Detection of Protein Aggregation Propensity Oliver Croad Efficient siRNA delivery and gene silencing Abdelkader Metwally

 

Particle Design and Engineering - Innovations for Inhalation
Speaker: Professor Peter York, University of Bradford

Formulation of combination and triple drug therapies via inhaled route
Speaker: Mr David Hipkiss, Prosonix Ltd

Short Papers from submitted Abstracts

	Lactose fluidization properties and their relationship to dry powder inhaler performance Miss Hanne Kinnunen The influence of sodium halides on the output and fine particle fraction of aerosols generated using air-jet and vibrating-mesh nebulisers Dr Abdelbary Elhissi The formulation and evaluation of a dry powder for pulmonary delivery in cystinosis Miss Barbara Buchan Organic Cation Transporters are Functional in Layers of the Human Bronchial Epithelial Cell Line Calu-3 Miss Manali Mukherjee

 

Session Chair: Dr Majella Lane, University of London

The Role of Hydrofiber® Dressings in Wound Healing
Hydrofiber® dressing Technology is an innovate addition to wound care. Evidence will show their ability to micro-contour to wound surfaces, provide good exudate management, and with the addition of silver lock in and kill bacteria thereby reducing wound bioburden.
Speaker: Dr Mike Walker, Convatec

Hydration and friction damage in skin occluded by incontinence pads
Speaker: Professor Alan Cottenden, University College London

Short Papers from submitted Abstracts

	Metrology Of The Stratum Corneum Mr Diar Mohammed Application of Biophysics and Bioengineering to the Assessment of Barrier Function Miss Quan Yang A Novel Polymeric Microneedle Formulation For The Transdermal Delivery Of Bacteriophages Miss Elizabeth Ryan

Session Chair: Mr Ken Leiper, Joint Pharmaceutical Analysis Group

Short Papers from submitted abstracts:

	Soltani Evaluation of the physico-chemical and biological properties of the proteasomal inhibitor PSI Mr Abderrezzaq Soltani The use of photocalorimetry to assess the photostability of nifedipine solutions Mr Luís Almeida e Sousa

Preparation and structural analysis of co-crystals (40 min)
Speaker: Professor Chris Frampton, Pharmorphix

Characterisation of Drug-Resin Complexes (40 min)
Ion exchange resins have shown great utility in taste masking. This presentation demonstrates that the choice of resin, resin particle size and the drug/resin ratio affects both the in vitro and in vivo release profiles of the candidate drug, as well as affecting the choice of preservative system.
Speaker: Dr David Elder, GlaxoSmithKline

Presentation of Geoffrey Phillips Analytical Science Award (10 min)
This award will be made to the presenter judged to have made the best presentation of a short paper, age under 35 years.
 

Quorum Sensing as a Target for Antimicrobial Chemotherapy
There are two broad strategies for the control of bacterial infections, either (a) kill the organism or (b) attenuate virulence such the infecting organism fails to adapt to the host environment and can be cleared by host defences. Anti-virulence agents offer several potential advantages including expanding the repertoire of bacterial targets, preserving the host microflora and exerting less selective pressure, which may result in decreased resistance. In many pathogens, virulence is co-ordinately controlled via sophisticated global regulatory systems such as quorum sensing. This is usually defined as cell population density dependent gene regulation and is mediated via self-generated extracellular signal molecules. These low molecular weight compounds or ‘autoinducers’ activate or repress QS target genes once a critical threshold concentration of signal has been reached. The key components of any QS ‘module’ are the QS signal synthase, the signal receptor and the signal molecule. QS systems thus offer multiple targets for chemical intervention through the blockade of QS signal synthesis, QS signal molecule degradation or the inhibition of QS signal reception. Such targets in conjunction with high throughput screens offer multiple opportunities for the design of synthetic inhibitors and the discovery of natural products for the treatment of infections caused by multi-antibiotic resistant bacteria.
Speaker: Professor Paul Williams, University of Nottingham

Bacteriophages as an Antibacterial Strategy
Speaker: Dr David Harper, BioControl Ltd

Immobilised bacteriophages for the control of biofilms on implanted medical devices
Speaker: Professor Geoff Hanlon, University of Brighton

Short Papers from submitted Abstracts:

	New Vaccines for Infectious Diseases Miss Aditi Pathak Inhibition of the bacterial metalloprotease, ZapA, a virulence factor of the opportunistic pathogen Proteus mirabilis Miss Louise Carson

 

Session Chair: Dr Gavin Reynolds, AstraZeneca

Using Predictive Tools for Rapid Formulation Development
This presentation will provide a compelling rationale for the use of predictive approaches to formulation design and development. It will provide several examples of practical and useful predictive tools, and will highlight their application during drug product development. The factors necessary for the success using this approach will also be discussed.
Speaker: Dr Bruno Hancock, Pfizer, USA

Short Papers from submitted Abstracts

	Numerical analysis of electrostatic effects during powder deposition using DEM/CFD Dr Chuanyu Wu A simple test to predict and understand the impact of unit operations on powder flow Dr Barry Crean Terahertz Pulsed Spectroscopy Study of Amino Acids and Gelatin Mr J Darkwah

Poster bites:

	Analytical solutions for roll compaction of pharmaceutical powders Dr James Andrews Effects of polymer type and drug/polymer interactions on the supersaturated celecoxib solutions Dr Osama Abu-Diak

 

Session Chairs: Dr Martin Whitaker, University of Sheffield

Understanding structure-disposition relationships for polylysine dendrimers: a route to enhanced tumour targeting?
Speaker: Professor Chris Porter, Monash University, Australia

Challenges in biomodelling of large molecules
Speaker: Professor Balaji Agoram, Pfizer

Short Papers from submitted Abstracts:

	Immunological Regulation in the Tumour Microenvironment Helen Angell Scrutiny of controlled release protein loaded PLGA microspheres using surface analytical techniques Mr Ali Rafati